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Anisometropia refers to a condition where there is an unequal refractive power between the two eyes. This means that one eye may require a different lens power than the other to achieve clear vision. This discrepancy can lead to various visual issues, including discomfort, double vision, or difficulty in depth perception, as the brain struggles to coordinate inputs from the differently focused eyes.

The other options describe different conditions that do not accurately reflect the nature of anisometropia. Equal refractive error in both eyes would describe a situation where both eyes have the same visual prescription, which is not the case in anisometropia. Both eyes having hyperopia addresses a specific type of refractive error, but anisometropia can involve any combination of myopia, hyperopia, and astigmatism, making this option too narrow. Low vision in one eye only does not necessarily denote anisometropia, as it could be due to other conditions that affect vision in one eye without indicating a refractive imbalance.